The Egyptian spiny mouse may hold clues to understanding human pregnancy better

About 8% – 12% of couples of reproductive age suffer from infertility and roughly 15% of all pregnancies end in miscarriage.

The underlying mechanisms of human pregnancy are still poorly understood. In part, this is because pregnancy works quite differently in most mammals.

However, recent research indicates the Egyptian spiny mouse, which menstruates as humans do, could offer an excellent model for research. Our new study, published in Scientific Reports, shows the lining of the mouse’s uterus, or endometrium, also grows in a human-like way to prepare for embryo implantation.

Important animal models

There are many reasons for miscarriage and other pregnancy complications, ranging from hormonal and vitamin imbalances to failure of placental development and impaired embryo implantation. To understand these conditions, researchers need to do experiments – but doing experiments on humans poses serious ethical, practical and financial challenges.

That is why researchers try to “model” the conditions in suitable laboratory animals. Animal models (using rodents in particular) have helped explain many aspects of human reproduction, but they are limited by fundamental differences between human reproduction and that of other species.

Less than 2% of all mammal species menstruate, with most instead having an oestrus cycle (“going on heat”). Aside from humans, most menstruating species are great apes or old-world monkeys.

Non-human primates like these would be the most biologically appropriate animals for modelling human reproduction. But their large size, complex welfare requirements and high costs have prevented their adoption as laboratory animals.

So, to study and manage human pregnancy more effectively, we need a more appropriate menstruating animal model of female reproduction.

Menstruating spiny mouse

The Egyptian spiny mouse (Acomys cahirinus) was recently shown to have human-like menstruation. This had never been seen before in any rodent, and the discovery gives researchers an unprecedented non-primate model for studying menstrual and gynaecological disorders.

Researchers from Monash University have since delved deeper into the mystery of spiny mouse reproductive biology. The researchers have provided an in-depth characterisation of the menstrual cycle, identified premenstrual syndrome-like behaviour and, most recently, early embryo implantation and pregnancy.

Endometrial growth

In our study published in Scientific Reports, we discovered that the lining of the spiny mouse’s uterus displays similar patterns of growth and receptivity to embryo implantation as other menstruating species.

Before an embryo can implant, the uterus lining must more than double in size and begin secreting the required proteins to encourage an embryo to implant correctly. This study demonstrated simultaneous increases in thickness and receptivity of the spiny mouse endometrium before embryo implantation, closely reflecting the events in other menstruating species.

Spiral arteries

In all menstruating species, spiral-shaped arteries grow in the uterine lining.

These spring-like arteries are vital in providing nutrients for a growing placenta and poorly functioning spiral arteries are associated with several pregnancy complications such as pre-eclampsia and intra-uterine growth restriction.

In our study, we observed the growth of spiral arteries prior to embryo implantation but also changes to their structure and function soon after. This also occurs during early pregnancy in other menstruating species including gorillas, chimpanzees and humans.

Looking to future

Although our knowledge of spiny mouse reproductive biology is in its infancy, what we do know is very encouraging.

This study is further proof for the unique reproduction of the spiny mouse and adds to the growing list of reproductive traits we share with this fascinating species. Not only do spiny mice have human-like menstruation, but this recent study demonstrates similarities of endometrial growth, receptivity and the critical role of spiral arteries during early pregnancy of menstrual species.

Further research into spiny mouse reproductive biology may reveal new treatment options for pregnancy complications. In turn, this could change how we treat and monitor pregnancy and lead to better outcomes.

Jarrod McKenna is a PhD candidate and academic tutor at Monash University.

This article first appeared on The Conversation.